Mechanics of coupling proton movements toc-ring rotation in ATP synthase
نویسندگان
چکیده
منابع مشابه
36 degrees step size of proton-driven c-ring rotation in FoF1-ATP synthase.
Synthesis of adenosine triphosphate ATP, the 'biological energy currency', is accomplished by F(o)F(1)-ATP synthase. In the plasma membrane of Escherichia coli, proton-driven rotation of a ring of 10 c subunits in the F(o) motor powers catalysis in the F(1) motor. Although F(1) uses 120 degrees stepping during ATP synthesis, models of F(o) predict either an incremental rotation of c subunits in...
متن کامل36 1 step size of proton - driven c - ring rotation in FoF 1 - ATP synthase
Synthesis of adenosine triphosphate ATP, the ‘biological energy currency’, is accomplished by FoF1-ATP synthase. In the plasma membrane of Escherichia coli, proton-driven rotation of a ring of 10 c subunits in the Fo motor powers catalysis in the F1 motor. Although F1 uses 1201 stepping during ATP synthesis, models of Fo predict either an incremental rotation of c subunits in 361 steps or large...
متن کاملstep size of proton - driven c - ring rotation in FoF 1 - ATP synthase
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متن کاملF(0) of ATP synthase is a rotary proton channel. Obligatory coupling of proton translocation with rotation of c-subunit ring.
Coupling of proton flow and rotation in the F(0) motor of ATP synthase was investigated using the thermophilic Bacillus PS3 enzyme expressed functionally in Escherichia coli cells. Cysteine residues introduced into the N-terminal regions of subunits b and c of ATP synthase (bL2C/cS2C) were readily oxidized by treating the expressing cells with CuCl(2) to form predominantly a b-c cross-link with...
متن کاملObstruction of transmembrane helical movements in subunit a blocks proton pumping by F1Fo ATP synthase.
Subunit a plays a key role in promoting H(+) transport-coupled rotary motion of the subunit c ring in F1Fo ATP synthase. H(+) binding and release occur at Asp-61 in the middle of the second transmembrane helix (TMH) of Fo subunit c. H(+) are thought to reach cAsp61 via aqueous half-channels formed by TMHs 2-5 of subunit a. Movements of TMH4 and TMH5 have been proposed to facilitate protonation ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2003
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(03)01101-3